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Anchoring Chromatin Loops to Cancer
Although some genomic rearrangements are caused by replication or transcription, the etiology of others is unclear. Reporting in Cell, Canela et al. (2017) reveal that type II topoisomerase-mediated release of torsional strain at chromosomal loop anchors generates DNA double-strand breaks that drive...
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| Опубликовано в: : | Dev Cell |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5859922/ https://ncbi.nlm.nih.gov/pubmed/28787588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.07.013 |
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