Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility

Luminal fluid reabsorption plays a fundamental role in male fertility. We demonstrated that the ubiquitous GPCR signaling proteins Gq and β-arrestin-1 are essential for fluid reabsorption because they mediate coupling between an orphan receptor ADGRG2 (GPR64) and the ion channel CFTR. A reduction in...

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Vydáno v:eLife
Hlavní autoři: Zhang, Dao-Lai, Sun, Yu-Jing, Ma, Ming-Liang, Wang, Yi-jing, Lin, Hui, Li, Rui-Rui, Liang, Zong-Lai, Gao, Yuan, Yang, Zhao, He, Dong-Fang, Lin, Amy, Mo, Hui, Lu, Yu-Jing, Li, Meng-Jing, Kong, Wei, Chung, Ka Young, Yi, Fan, Li, Jian-Yuan, Qin, Ying-Ying, Li, Jingxin, Thomsen, Alex R B, Kahsai, Alem W, Chen, Zi-Jiang, Xu, Zhi-Gang, Liu, Mingyao, Li, Dali, Yu, Xiao, Sun, Jin-Peng
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839696/
https://ncbi.nlm.nih.gov/pubmed/29393851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33432
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