Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer

BACKGROUND: Laron syndrome is an autosomal disease resulting from mutations in the growth hormone receptor (GHR) gene. The only therapeutic treatment for Laron syndrome is recombinant insulin-like growth factor I (IGF-I), which has been shown to have various side effects. The improved Laron syndrome...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Yu, Honghao, Long, Weihu, Zhang, Xuezeng, Xu, Kaixiang, Guo, Jianxiong, Zhao, Heng, Li, Honghui, Qing, Yubo, Pan, Weirong, Jia, Baoyu, Zhao, Hong-Ye, Huang, Xingxu, Wei, Hong-Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828148/
https://ncbi.nlm.nih.gov/pubmed/29482569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1409-7
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