Effect of desipramine on patients with breathing disorders in RETT syndrome

OBJECTIVE: Rett Syndrome (RTT) is a severe neurodevelopmental condition with breathing disorders, affecting around one in 10,000 female births. Desipramine, a noradrenaline reuptake inhibitor, reduced the number of apneas in Mecp2‐deficient mice, a model of RTT. We planned a phase 2 trial to test it...

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Veröffentlicht in:Ann Clin Transl Neurol
Hauptverfasser: Mancini, Josette, Dubus, Jean‐Christophe, Jouve, Elisabeth, Roux, Jean‐Christophe, Franco, Patricia, Lagrue, Emmanuelle, Castelnau, Pierre, Cances, Claude, Chaix, Yves, Rougeot‐Jung, Christelle, Cornu, Catherine, Desportes, Vincent, Vallée, Louis, Bahi‐Buisson, Nadia, Truillet, Romain, Attolini, Laurence, Villard, Laurent, Blin, Olivier, Micallef, Joëlle
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817841/
https://ncbi.nlm.nih.gov/pubmed/29468173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.468
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