D-Pinitol alleviates cyclosporine A-induced renal tubulointerstitial fibrosis via activating Sirt1 and Nrf2 antioxidant pathways

Although the mechanism of cyclosporine A (CsA)-induced renal injury remains to be fully elucidated, accumulating evidence suggests that oxidative stress is critical in producing CsA-induced structural and functional renal impairment. The present study investigated the effect of D-pinitol, a cyclitol...

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Veröffentlicht in:Int J Mol Med
Hauptverfasser: Koh, Eun Sil, Kim, Soojeong, Kim, Minyoung, Hong, Yu Ah, Shin, Seok Joon, Park, Cheol Whee, Chang, Yoon Sik, Chung, Sungjin, Kim, Ho-Shik
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2018
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810208/
https://ncbi.nlm.nih.gov/pubmed/29393366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3408
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