Phospholipid remodeling and cholesterol availability regulate intestinal stemness and tumorigenesis

Adequate availability of cellular building blocks, including lipids, is a prerequisite for cellular proliferation, but excess dietary lipids are linked to increased cancer risk. Despite these connections, specific regulatory relationships between membrane composition, intestinal stem cell (ISC) prol...

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Udgivet i:Cell Stem Cell
Main Authors: Wang, Bo, Rong, Xin, Palladino, Elisa N.D., Wang, Jiafang, Fogelman, Alan M., Martín, Martín G., Alrefai, Waddah A., Ford, David A., Tontonoz, Peter
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807072/
https://ncbi.nlm.nih.gov/pubmed/29395055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.12.017
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