Functional Interrogation and Mining of Natively-Paired Human V(H):V(L) Antibody Repertoires

We present a technology to screen natively-paired human antibody repertoires from millions of B cells. Libraries of natively-paired variable region heavy and light (V(H):V(L)) amplicons are expressed in a yeast display platform that is optimized for human Fab surface expression. Using our method we...

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Publicado no:Nat Biotechnol
Main Authors: Wang, Bo, DeKosky, Brandon J., Timm, Morgan R., Lee, Jiwon, Normandin, Erica, Misasi, John, Kong, Rui, McDaniel, Jonathan R., Delidakis, George, Leigh, Kendra E., Niezold, Thomas, Choi, Chang W., Viox, Elise G., Fahad, Ahmed, Cagigi, Alberto, Ploquin, Aurélie, Leung, Kwanyee, Yang, Eun S., Kong, Wing-Pui, Voss, William N., Schmidt, Aaron G., Moody, M. Anthony, Ambrozak, David R., Henry, Amy R., Laboune, Farida, Ledgerwood, Julie E., Graham, Barney S., Connors, Mark, Douek, Daniel C., Sullivan, Nancy J., Ellington, Andrew D., Mascola, John R., Georgiou, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801115/
https://ncbi.nlm.nih.gov/pubmed/29309060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4052
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