Functional Interrogation and Mining of Natively-Paired Human V(H):V(L) Antibody Repertoires

We present a technology to screen natively-paired human antibody repertoires from millions of B cells. Libraries of natively-paired variable region heavy and light (V(H):V(L)) amplicons are expressed in a yeast display platform that is optimized for human Fab surface expression. Using our method we...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Biotechnol
Egile Nagusiak: Wang, Bo, DeKosky, Brandon J., Timm, Morgan R., Lee, Jiwon, Normandin, Erica, Misasi, John, Kong, Rui, McDaniel, Jonathan R., Delidakis, George, Leigh, Kendra E., Niezold, Thomas, Choi, Chang W., Viox, Elise G., Fahad, Ahmed, Cagigi, Alberto, Ploquin, Aurélie, Leung, Kwanyee, Yang, Eun S., Kong, Wing-Pui, Voss, William N., Schmidt, Aaron G., Moody, M. Anthony, Ambrozak, David R., Henry, Amy R., Laboune, Farida, Ledgerwood, Julie E., Graham, Barney S., Connors, Mark, Douek, Daniel C., Sullivan, Nancy J., Ellington, Andrew D., Mascola, John R., Georgiou, George
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801115/
https://ncbi.nlm.nih.gov/pubmed/29309060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4052
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