The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D(2) receptor

SB269652 is a negative allosteric modulator of the dopamine D(2) receptor (D(2)R) yet possesses structural similarity to ligands with a competitive mode of interaction. In this study, we aimed to understand the ligand-receptor interactions that confer its allosteric action. We combined site-directed...

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Detalhes bibliográficos
Publicado no:Biochem Pharmacol
Main Authors: Draper-Joyce, Christopher J., Michino, Mayako, Verma, Ravi Kumar, Herenbrink, Carmen Klein, Shonberg, Jeremy, Kopinathan, Anitha, Scammells, Peter J., Capuano, Ben, Thal, David M., Javitch, Jonathan A., Christopoulos, Arthur, Shi, Lei, Lane, J. Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800995/
https://ncbi.nlm.nih.gov/pubmed/29325769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.01.002
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