The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D(2) receptor

SB269652 is a negative allosteric modulator of the dopamine D(2) receptor (D(2)R) yet possesses structural similarity to ligands with a competitive mode of interaction. In this study, we aimed to understand the ligand-receptor interactions that confer its allosteric action. We combined site-directed...

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Publicat a:Biochem Pharmacol
Autors principals: Draper-Joyce, Christopher J., Michino, Mayako, Verma, Ravi Kumar, Herenbrink, Carmen Klein, Shonberg, Jeremy, Kopinathan, Anitha, Scammells, Peter J., Capuano, Ben, Thal, David M., Javitch, Jonathan A., Christopoulos, Arthur, Shi, Lei, Lane, J. Robert
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800995/
https://ncbi.nlm.nih.gov/pubmed/29325769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.01.002
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