Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-(1-hydroxypentyl)-benzoate, in rats and dogs

Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB) is a novel pro-drug of 3-n-butylphthalide (dl-NBP) that is used to treat ischemic stroke. Currently, dl-PHPB is in phase II–III clinical trials in China. In this study, we investigated the conversion and pharmacokinetics profiles of dl-PHPB in vitro a...

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Publicado no:Acta Pharmacol Sin
Main Authors: Li, Jiang, Xu, Shao-feng, Peng, Ying, Feng, Nan, Wang, Ling, Wang, Xiao-liang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800474/
https://ncbi.nlm.nih.gov/pubmed/28905934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.90
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