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Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-(1-hydroxypentyl)-benzoate, in rats and dogs

Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB) is a novel pro-drug of 3-n-butylphthalide (dl-NBP) that is used to treat ischemic stroke. Currently, dl-PHPB is in phase II–III clinical trials in China. In this study, we investigated the conversion and pharmacokinetics profiles of dl-PHPB in vitro a...

詳細記述

保存先:
書誌詳細
出版年:Acta Pharmacol Sin
主要な著者: Li, Jiang, Xu, Shao-feng, Peng, Ying, Feng, Nan, Wang, Ling, Wang, Xiao-liang
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800474/
https://ncbi.nlm.nih.gov/pubmed/28905934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.90
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