Newcastle disease virus co‐expressing interleukin 7 and interleukin 15 modified tumor cells as a vaccine for cancer immunotherapy

Interleukin 15 (IL15) and IL7 are two cytokines essential for T cell development and homeostasis. In order to improve the antitumor activity by Newcastle disease virus (NDV)‐modified tumor vaccine, we generated a recombinant NDV co‐expressing IL15 and IL7 (LX/IL(15+7)) through incorporation of a 2A...

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發表在:Cancer Sci
Main Authors: Xu, Xiaojing, Sun, Qing, Mei, Yu, Liu, Yonghao, Zhao, Lixiang
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2018
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797827/
https://ncbi.nlm.nih.gov/pubmed/29224228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13468
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