Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

OBJECTIVE: Primary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver transplantation or death. Little is known about the genetic contribution to the severity and progression of PSC. The aim of this study is to id...

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Published in:Gut
Main Authors: Alberts, Rudi, de Vries, Elisabeth M G, Goode, Elizabeth C, Jiang, Xiaojun, Sampaziotis, Fotis, Rombouts, Krista, Böttcher, Katrin, Folseraas, Trine, Weismüller, Tobias J, Mason, Andrew L, Wang, Weiwei, Alexander, Graeme, Alvaro, Domenico, Bergquist, Annika, Björkström, Niklas K, Beuers, Ulrich, Björnsson, Einar, Boberg, Kirsten Muri, Bowlus, Christopher L, Bragazzi, Maria C, Carbone, Marco, Chazouillères, Olivier, Cheung, Angela, Dalekos, Georgios, Eaton, John, Eksteen, Bertus, Ellinghaus, David, Färkkilä, Martti, Festen, Eleonora A M, Floreani, Annarosa, Franceschet, Irene, Gotthardt, Daniel Nils, Hirschfield, Gideon M, van Hoek, Bart, Holm, Kristian, Hohenester, Simon, Hov, Johannes Roksund, Imhann, Floris, Invernizzi, Pietro, Juran, Brian D, Lenzen, Henrike, Lieb, Wolfgang, Liu, Jimmy Z, Marschall, Hanns-Ulrich, Marzioni, Marco, Melum, Espen, Milkiewicz, Piotr, Müller, Tobias, Pares, Albert, Rupp, Christian, Rust, Christian, Sandford, Richard N, Schramm, Christoph, Schreiber, Stefan, Schrumpf, Erik, Silverberg, Mark S, Srivastava, Brijesh, Sterneck, Martina, Teufel, Andreas, Vallier, Ludovic, Verheij, Joanne, Vila, Arnau Vich, de Vries, Boudewijn, Zachou, Kalliopi, Chapman, Roger W, Manns, Michael P, Pinzani, Massimo, Rushbrook, Simon M, Lazaridis, Konstantinos N, Franke, Andre, Anderson, Carl A, Karlsen, Tom H, Ponsioen, Cyriel Y, Weersma, Rinse K
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797498/
https://ncbi.nlm.nih.gov/pubmed/28779025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-313598
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