PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen‐1 signalling

BACKGROUND AND PURPOSE: Following inflammatory stimuli, neutrophils are recruited to sites of inflammation and exert effector functions that often have deleterious effects on tissue integrity, which can lead to organ failure. Bruton's tyrosine kinase (Btk) is expressed in neutrophils and consti...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Herter, Jan M, Margraf, Andreas, Volmering, Stephanie, Correia, Benedito Eduardo, Bradshaw, J Michael, Bisconte, Angelina, Hill, Ronald J, Langrish, Claire L, Lowell, Clifford A, Zarbock, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773957/
https://ncbi.nlm.nih.gov/pubmed/29130484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14090
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