PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen‐1 signalling

BACKGROUND AND PURPOSE: Following inflammatory stimuli, neutrophils are recruited to sites of inflammation and exert effector functions that often have deleterious effects on tissue integrity, which can lead to organ failure. Bruton's tyrosine kinase (Btk) is expressed in neutrophils and consti...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Herter, Jan M, Margraf, Andreas, Volmering, Stephanie, Correia, Benedito Eduardo, Bradshaw, J Michael, Bisconte, Angelina, Hill, Ronald J, Langrish, Claire L, Lowell, Clifford A, Zarbock, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773957/
https://ncbi.nlm.nih.gov/pubmed/29130484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14090
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