Metformin Enhanced in Vitro Radiosensitivity Associates with G2/M Cell Cycle Arrest and Elevated Adenosine-5’-monophosphate-activated Protein Kinase Levels in Glioblastoma

BACKGROUND: It is hypothesized that metabolism plays a strong role in cancer cell regulation. We have recently demonstrated improved progression-free survival in patients with glioblastoma who received metformin as an antidiabetic substance during chemoradiation. Although metformin is well-establish...

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Detalhes bibliográficos
Publicado no:Radiol Oncol
Main Authors: Adeberg, Sebastian, Bernhardt, Denise, Harrabi, Semi B., Nicolay, Nils H., Hörner-Rieber, Juliane, König, Laila, Repka, Michael, Mohr, Angela, Abdollahi, Amir, Weber, Klaus-Josef, Debus, Juergen, Rieken, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: De Gruyter Open 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765320/
https://ncbi.nlm.nih.gov/pubmed/29333122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/raon-2017-0042
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