A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

BACKGROUND: Senescence is a fundamental biological process implicated in various pathologies, including cancer. Regarding carcinogenesis, senescence signifies, at least in its initial phases, an anti-tumor response that needs to be circumvented for cancer to progress. Micro-RNAs, a subclass of regul...

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Bibliographic Details
Published in:BMC Genomics
Main Authors: Komseli, Eirini-Stavroula, Pateras, Ioannis S., Krejsgaard, Thorbjørn, Stawiski, Konrad, Rizou, Sophia V., Polyzos, Alexander, Roumelioti, Fani-Marlen, Chiourea, Maria, Mourkioti, Ioanna, Paparouna, Eleni, Zampetidis, Christos P., Gumeni, Sentiljana, Trougakos, Ioannis P., Pefani, Dafni-Eleftheria, O’Neill, Eric, Gagos, Sarantis, Eliopoulos, Aristides G., Fendler, Wojciech, Chowdhury, Dipanjan, Bartek, Jiri, Gorgoulis, Vassilis G.
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Methodology Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5763532/
https://ncbi.nlm.nih.gov/pubmed/29321003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-4375-1
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