“Inverse Drug Discovery” strategy to identify proteins that are targeted by latent electrophiles – exemplified by arylfluorosulfates

Drug candidates are generally discovered using biochemical screens employing an isolated target protein or by utilizing cell-based phenotypic assays. Both non-covalent and covalent hits emerge from such endeavors. Herein, we exemplify an “Inverse Drug Discovery” strategy in which organic compounds o...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Mortenson, David E., Brighty, Gabriel J., Plate, Lars, Bare, Grant, Chen, Wentao, Li, Suhua, Wang, Hua, Cravatt, Benjamin F., Forli, Stefano, Powers, Evan T., Sharpless, K. Barry, Wilson, Ian A., Kelly, Jeffery W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762408/
https://ncbi.nlm.nih.gov/pubmed/29265822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08366
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