Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency

Programmable nucleases, such as Cas9, are used for precise genome editing by homology-dependent repair (HDR)(1–3). However, HDR efficiency is constrained by competition from other double-strand break (DSB) repair pathways, including non-homologous end-joining (NHEJ)(4). We report the discovery of a...

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Publié dans:Nat Biotechnol
Auteurs principaux: Canny, Marella D., Moatti, Nathalie, Wan, Leo C.K., Fradet-Turcotte, Amélie, Krasner, Danielle, Mateos-Gomez, Pedro A., Zimmermann, Michal, Orthwein, Alexandre, Juang, Yu-Chi, Zhang, Wei, Noordermeer, Sylvie M., Seclen, Eduardo, Wilson, Marcus D., Vorobyov, Andrew, Munro, Meagan, Ernst, Andreas, Ng, Timothy F., Cho, Tiffany, Cannon, Paula M., Sidhu, Sachdev S., Sicheri, Frank, Durocher, Daniel
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762392/
https://ncbi.nlm.nih.gov/pubmed/29176614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4021
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