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RKIP inhibits NF-κB in cancer cells by regulating upstream signaling components of the IκB kinase complex
RKIP was first identified as an inhibitor of the Raf-MEK-ERK signaling pathway. RKIP was also found to play an important role in the NF-ΚB pathway. Genetic and biochemical studies demonstrated that RKIP functioned as a scaffold protein facilitating the phosphorylation of IκB by upstream kinases. How...
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| Опубликовано в: : | FEBS Lett |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5748157/ https://ncbi.nlm.nih.gov/pubmed/20043910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.12.051 |
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