RKIP inhibits NF-κB in cancer cells by regulating upstream signaling components of the IκB kinase complex

RKIP was first identified as an inhibitor of the Raf-MEK-ERK signaling pathway. RKIP was also found to play an important role in the NF-ΚB pathway. Genetic and biochemical studies demonstrated that RKIP functioned as a scaffold protein facilitating the phosphorylation of IκB by upstream kinases. How...

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Bibliographic Details
Published in:FEBS Lett
Main Authors: Tang, Huihui, Park, Sungdae, Sun, Shao-Cong, Trumbly, Robert, Ren, Gang, Tsung, Eric, Yeung, Kam C.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748157/
https://ncbi.nlm.nih.gov/pubmed/20043910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.12.051
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