mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

Antigen-presenting cells (APCs) occupy diverse anatomical tissues, but their tissue-restricted homeostasis remains poorly understood. Here, working in mouse models of inflammation, we found that mTOR-dependent metabolic adaptation was required at discrete locations. mTOR was dispensable for DC homeo...

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Publicado no:Science
Main Authors: Sinclair, Charles, Bommakanti, Gayathri, Gardinassi, Luiz, Loebbermann, Jens, Johnson, Matthew Joseph, Hakimpour, Paul, Hagan, Thomas, Benitez, Lydia, Todor, Andrei, Machiah, Deepa, Oriss, Timothy, Ray, Anuradha, Bosinger, Steven, Ravindran, Rajesh, Li, Shuzhao, Pulendran, Bali
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746055/
https://ncbi.nlm.nih.gov/pubmed/28798047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaj2155
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