The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics

Kidney podocytes represent a key constituent of the glomerular filtration barrier. Identifying the molecular mechanisms of podocyte injury and survival is important for better understanding and management of kidney diseases. KIBRA (kidney brain protein), an upstream regulator of the Hippo signaling...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Meliambro, Kristin, Wong, Jenny S., Ray, Justina, Calizo, Rhodora C., Towne, Sara, Cole, Beatriz, El Salem, Fadi, Gordon, Ronald E., Kaufman, Lewis, He, John C., Azeloglu, Evren U., Campbell, Kirk N.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Molecular Bases of Disease
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743086/
https://ncbi.nlm.nih.gov/pubmed/28982981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.819029
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