Upregulations of Clcn3 and P-Gp Provoked by Lens Osmotic Expansion in Rat Galactosemic Cataract

OBJECTIVE: Lens osmotic expansion, provoked by overactivated aldose reductase (AR), is the most essential event of sugar cataract. Chloride channel 3 (Clcn3) is a volume-sensitive channel, mainly participating in the regulation of cell fundamental volume, and P-glycoprotein (P-gp) acts as its modula...

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Bibliographic Details
Published in:J Diabetes Res
Main Authors: Ji, Lixia, Cheng, Lixia, Yang, Zhihong
Format: Artigo
Language:Inglês
Published: Hindawi 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735653/
https://ncbi.nlm.nih.gov/pubmed/29527534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/3472735
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