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Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond

Rap/Rgg/NprR/PlcR/PrgX (RRNPP) quorum-sensing systems use extracellular peptide pheromones that are detected by cytoplasmic receptors to regulate gene expression in firmicute bacteria. Rgg-type receptors are allosterically regulated through direct pheromone binding to control transcriptional activit...

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Foilsithe in:J Biol Chem
Main Authors: Wilkening, Reid V., Capodagli, Glenn C., Khataokar, Atul, Tylor, Kaitlyn M., Neiditch, Matthew B., Federle, Michael J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733591/
https://ncbi.nlm.nih.gov/pubmed/29030429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.801670
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