Discovery of APD371: Identification of a Highly Potent and Selective CB(2) Agonist for the Treatment of Chronic Pain

[Image: see text] The discovery of a novel, selective and fully efficacious CB(2) agonist with satisfactory pharmacokinetic and pharmaceutical properties is described. Compound 6 was efficacious in a rat model of osteoarthritis pain following oral administration and, in contrast to morphine, maintai...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Han, Sangdon, Thoresen, Lars, Jung, Jae-Kyu, Zhu, Xiuwen, Thatte, Jayant, Solomon, Michelle, Gaidarov, Ibragim, Unett, David J., Yoon, Woo Hyun, Barden, Jeremy, Sadeque, Abu, Usmani, Amin, Chen, Chuan, Semple, Graeme, Grottick, Andrew J., Al-Shamma, Hussein, Christopher, Ronald, Jones, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733264/
https://ncbi.nlm.nih.gov/pubmed/29259753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00396
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