Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma

Human osteosarcoma is considered a malignant tumor with poor prognosis that readily metastasizes. Tetrahydrocurcumin (THC) has been reported to have anti-tumor activity in numerous tumors. In addition, hypoxia-inducible factor-1α (HIF-1α) has been demonstrated to be associated with tumor metastasis...

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Vydáno v:Oncotarget
Hlavní autoři: Zhang, Yan, Liu, Ying, Zou, Jilong, Yan, Lixin, Du, Wei, Zhang, Yafeng, Sun, Hanliang, Lu, Peng, Geng, Shuo, Gu, Rui, Zhang, Hongyue, Bi, Zhenggang
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710911/
https://ncbi.nlm.nih.gov/pubmed/29207631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19845
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