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Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity
Protein misfolding results in the accumulation of aggregated β-sheet-rich structures in Parkinson’s disease (PD) and Alzheimer’s disease (AD). The toxic oligomer hypothesis stipulates that prefibrillar assemblies, such as soluble oligomers or protofibrils, are responsible for the poor prognosis of t...
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| Published in: | Biochemistry |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5706464/ https://ncbi.nlm.nih.gov/pubmed/26799377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01168 |
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