Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis

Crescentic rapidly progressive glomerulonephritis (RPGN) represents the most aggressive form of acquired glomerular disease. While most therapeutic approaches involve potentially toxic immunosuppressive strategies, the pathophysiology remains incompletely understood. Podocytes are glomerular epithel...

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Publicado no:Nat Commun
Main Authors: Henique, Carole, Bollée, Guillaume, Loyer, Xavier, Grahammer, Florian, Dhaun, Neeraj, Camus, Marine, Vernerey, Julien, Guyonnet, Léa, Gaillard, François, Lazareth, Hélène, Meyer, Charlotte, Bensaada, Imane, Legrès, Luc, Satoh, Takashi, Akira, Shizuo, Bruneval, Patrick, Dimmeler, Stefanie, Tedgui, Alain, Karras, Alexandre, Thervet, Eric, Nochy, Dominique, Huber, Tobias B., Mesnard, Laurent, Lenoir, Olivia, Tharaux, Pierre-Louis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705755/
https://ncbi.nlm.nih.gov/pubmed/29184126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01885-7
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