Intramolecular autoinhibition of checkpoint kinase 1 is mediated by conserved basic motifs of the C-terminal kinase–associated 1 domain

Precise control of the cell cycle allows for timely repair of genetic material prior to replication. One factor intimately involved in this process is checkpoint kinase 1 (Chk1), a DNA damage repair inducing Ser/Thr protein kinase that contains an N-terminal kinase domain and a C-terminal regulatory...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Emptage, Ryan P., Schoenberger, Megan J., Ferguson, Kathryn M., Marmorstein, Ronen
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704483/
https://ncbi.nlm.nih.gov/pubmed/28972186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.811265
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