Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT

PKR is a cellular kinase involved in the regulation of the integrative stress response (ISR) and pro-inflammatory pathways. Two N-terminal dsRNA Binding Domains (DRBD) are required for activation of PKR, by interaction with either dsRNA or PACT, another cellular DRBD-containing protein. A role for P...

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Udgivet i:Sci Rep
Main Authors: Dabo, Stephanie, Maillard, Patrick, Collados Rodriguez, Milagros, Hansen, Marianne Doré, Mazouz, Sabrina, Bigot, Donna-Joe, Tible, Marion, Janvier, Geneviève, Helynck, Olivier, Cassonnet, Patricia, Jacob, Yves, Bellalou, Jacques, Gatignol, Anne, Patel, Rekha C., Hugon, Jacques, Munier-Lehmann, Hélène, Meurs, Eliane F.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701060/
https://ncbi.nlm.nih.gov/pubmed/29170442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16089-8
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