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Highly expressed genes evolve under strong epistasis from a proteome-wide scan in E. coli
Epistasis or the non-additivity of mutational effects is a major force in protein evolution, but it has not been systematically quantified at the level of a proteome. Here, we estimated the extent of epistasis for 2,382 genes in E. coli using several hundreds of orthologs for each gene within the cl...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5696520/ https://ncbi.nlm.nih.gov/pubmed/29158562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16030-z |
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