Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing

Delivering isotopic tracers for metabolic studies in rodents without overt stress is challenging. Current methods achieve low label enrichment in proteins and lipids. Here, we report noninvasive introduction of (13)C(6)-glucose via a stress-free, ad libitum liquid diet. Using NMR and ion chromatogra...

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Udgivet i:Nat Commun
Main Authors: Sun, Ramon C., Fan, Teresa W.-M., Deng, Pan, Higashi, Richard M., Lane, Andrew N., Le, Anh-Thu, Scott, Timothy L., Sun, Qiushi, Warmoes, Marc O., Yang, Ye
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696342/
https://ncbi.nlm.nih.gov/pubmed/29158483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01518-z
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