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BMI1 reduces ATR activation and signalling caused by hydroxyurea
BMI1 facilitates DNA damage response (DDR) induced by double strand DNA breaks; however, it remains unknown whether BMI1 functions in single strand DNA (ssDNA) lesions-initiated DDR. We report here that BMI1 reduces hydroxyurea-elicited ATR activation, thereby reducing the S-phase checkpoints. Hydro...
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| Veröffentlicht in: | Oncotarget |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Impact Journals LLC
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5685703/ https://ncbi.nlm.nih.gov/pubmed/29163782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21111 |
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