Anti-Jagged immunotherapy inhibits MDSCs and overcomes tumor-induced tolerance

Myeloid-derived suppressor cells (MDSCs) are a major obstacle to promising forms of cancer immunotherapy, but tools to broadly limit their immunoregulatory effects remain lacking. In this study, we assessed the therapeutic effect of the humanized anti-Jagged1/2 blocking antibody CTX014 on MDSC-media...

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Vydáno v:Cancer Res
Hlavní autoři: Sierra, Rosa A., Trillo-Tinoco, Jimena, Mohamed, Eslam, Yu, Lolie, Achyut, Bhagelu R., Arbab, Ali, Bradford, Jennifer W., Osborne, Barbara A., Miele, Lucio, Rodriguez, Paulo C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679354/
https://ncbi.nlm.nih.gov/pubmed/28904063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0357
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