MicroRNAs Induce a Permissive Chromatin Environment That Enables Neuronal Subtype-specific Reprogramming of Adult Human Fibroblasts

Directed reprogramming of human fibroblasts into fully-differentiated neurons requires massive changes in epigenetic and transcriptional states. Induction of a chromatin environment permissive to acquiring neuronal subtype identity is therefore a major barrier to fate conversion. Here we show that t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Abernathy, Daniel G., Kim, Woo Kyung, McCoy, Matthew J., Lake, Allison M., Ouwenga, Rebecca, Lee, Seong Won, Xing, Xiaoyun, Li, Daofeng, Lee, Hyung Joo, Heuckeroth, Robert O., Dougherty, Joseph D., Wang, Ting, Yoo, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679239/
https://ncbi.nlm.nih.gov/pubmed/28886366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.08.002
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados