MicroRNAs Induce a Permissive Chromatin Environment That Enables Neuronal Subtype-specific Reprogramming of Adult Human Fibroblasts

Directed reprogramming of human fibroblasts into fully-differentiated neurons requires massive changes in epigenetic and transcriptional states. Induction of a chromatin environment permissive to acquiring neuronal subtype identity is therefore a major barrier to fate conversion. Here we show that t...

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Pubblicato in:Cell Stem Cell
Autori principali: Abernathy, Daniel G., Kim, Woo Kyung, McCoy, Matthew J., Lake, Allison M., Ouwenga, Rebecca, Lee, Seong Won, Xing, Xiaoyun, Li, Daofeng, Lee, Hyung Joo, Heuckeroth, Robert O., Dougherty, Joseph D., Wang, Ting, Yoo, Andrew S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679239/
https://ncbi.nlm.nih.gov/pubmed/28886366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.08.002
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