MicroRNAs Induce a Permissive Chromatin Environment That Enables Neuronal Subtype-specific Reprogramming of Adult Human Fibroblasts

Directed reprogramming of human fibroblasts into fully-differentiated neurons requires massive changes in epigenetic and transcriptional states. Induction of a chromatin environment permissive to acquiring neuronal subtype identity is therefore a major barrier to fate conversion. Here we show that t...

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Библиографические подробности
Опубликовано в: :Cell Stem Cell
Главные авторы: Abernathy, Daniel G., Kim, Woo Kyung, McCoy, Matthew J., Lake, Allison M., Ouwenga, Rebecca, Lee, Seong Won, Xing, Xiaoyun, Li, Daofeng, Lee, Hyung Joo, Heuckeroth, Robert O., Dougherty, Joseph D., Wang, Ting, Yoo, Andrew S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679239/
https://ncbi.nlm.nih.gov/pubmed/28886366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.08.002
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