Reversal of 5-fluorouracil resistance by EGCG is mediate by inactivation of TFAP2A/VEGF signaling pathway and down-regulation of MDR-1 and P-gp expression in gastric cancer

The effect of 5-fluorouracil (5-FU) chemotherapy for gastric cancer (GC) is limited by drug-resistance. To conquer this drug-resistance, various treatments including combination therapy have been used, but the overall survival has not been improved yet. In our current study, 5-FU resistant GC cells,...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Tang, Hongsheng, Zeng, Lisi, Wang, Jiahong, Zhang, Xiangliang, Ruan, Qiang, Wang, Jin, Cui, Shuzhong, Yang, Dinghua
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669933/
https://ncbi.nlm.nih.gov/pubmed/29137307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20666
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