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Human iPSC-derived cerebral organoids model cellular features of lissencephaly and reveal prolonged mitosis of outer radial glia

Classical lissencephaly is a genetic neurological disorder associated with mental retardation and intractable epilepsy, and Miller Dieker Syndrome (MDS) is the most severe form of the disease. In this study, to investigate effects of MDS on human progenitor subtypes that control neuronal output and...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Stem Cell
Egile Nagusiak: Bershteyn, Marina, Nowakowski, Tomasz J., Pollen, Alex A., Di Lullo, Elizabeth, Nene, Aishwarya, Wynshaw-Boris, Anthony, Kriegstein, Arnold R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667944/
https://ncbi.nlm.nih.gov/pubmed/28111201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.12.007
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