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Human iPSC-derived cerebral organoids model cellular features of lissencephaly and reveal prolonged mitosis of outer radial glia
Classical lissencephaly is a genetic neurological disorder associated with mental retardation and intractable epilepsy, and Miller Dieker Syndrome (MDS) is the most severe form of the disease. In this study, to investigate effects of MDS on human progenitor subtypes that control neuronal output and...
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| Publicado en: | Cell Stem Cell |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5667944/ https://ncbi.nlm.nih.gov/pubmed/28111201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.12.007 |
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