Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation

Pyrazinamide is the main driver of sterilizing effect in the standard regimen in adults and older children, and this effect is concentration-dependent. Tuberculosis patients co-infected with human immunodeficiency virus (HIV) have an increased risk for poor tuberculosis treatment outcomes and advers...

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Publicado en:PLoS One
Autores principales: Vinnard, Christopher, Ravimohan, Shruthi, Tamuhla, Neo, Pasipanodya, Jotam, Srivastava, Shashikant, Modongo, Chawangwa, Zetola, Nicola M., Weissman, Drew, Gumbo, Tawanda, Bisson, Gregory P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667771/
https://ncbi.nlm.nih.gov/pubmed/29095954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187624
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