Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation

Pyrazinamide is the main driver of sterilizing effect in the standard regimen in adults and older children, and this effect is concentration-dependent. Tuberculosis patients co-infected with human immunodeficiency virus (HIV) have an increased risk for poor tuberculosis treatment outcomes and advers...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Vinnard, Christopher, Ravimohan, Shruthi, Tamuhla, Neo, Pasipanodya, Jotam, Srivastava, Shashikant, Modongo, Chawangwa, Zetola, Nicola M., Weissman, Drew, Gumbo, Tawanda, Bisson, Gregory P.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667771/
https://ncbi.nlm.nih.gov/pubmed/29095954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187624
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