Maternal high-fat diet impairs glucose metabolism, β-cell function and proliferation in the second generation of offspring rats

BACKGROUND: This study aimed to assess the impact of perinatal high-fat (HF) diet in female Sprague-Dawley rats (F0) on glucose metabolism and islet function in their early life of second-generation of offspring (F2). METHODS: F0 rats were fed with a standard chow (SC) or HF diet for 8 weeks before...

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Published in:Nutr Metab (Lond)
Main Authors: Huang, Yan-Hong, Ye, Ting-Ting, Liu, Chong-Xiao, Wang, Lei, Chen, Yuan-Wen, Dong, Yan
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667458/
https://ncbi.nlm.nih.gov/pubmed/29118817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12986-017-0222-2
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