Dynamic regulation of EZH2 from HPSc to hepatocyte-like cell fate

Currently, drug metabolization and toxicity studies rely on the use of primary human hepatocytes and hepatoma cell lines, which both have conceivable limitations. Human pluripotent stem cell (hPSC)—derived hepatocyte-like cells (HLCs) are an alternative and valuable source of hepatocytes that can ov...

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Pubblicato in:PLoS One
Autori principali: Pistoni, Mariaelena, Helsen, Nicky, Vanhove, Jolien, Boon, Ruben, Xu, Zhuofei, Ordovas, Laura, Verfaillie, Catherine M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665677/
https://ncbi.nlm.nih.gov/pubmed/29091973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186884
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