Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect

Aberrant alternative splicing and epigenetic changes are both associated with various cancers, but epigenetic regulation of alternative splicing in cancer is largely unknown. Here we report that the intragenic DNA methylation-mediated binding of Brother of Regulator of Imprinted Sites (BORIS) at the...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Singh, Smriti, Narayanan, Sathiya Pandi, Biswas, Kajal, Gupta, Amit, Ahuja, Neha, Yadav, Sandhya, Panday, Rajendra Kumar, Samaiya, Atul, Sharan, Shyam K., Shukla, Sanjeev
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2017
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664520/
https://ncbi.nlm.nih.gov/pubmed/29073069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708447114
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