Bosutinib versus Placebo for Autosomal Dominant Polycystic Kidney Disease

Overactivation of Src has been linked to the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD). This phase 2, multisite study assessed the efficacy and safety of bosutinib, an oral dual Src/Bcr-Abl tyrosine kinase inhibitor, in patients with ADPKD. Patients with ADPKD, eGFR≥60 ml/...

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Foilsithe in:J Am Soc Nephrol
Main Authors: Tesar, Vladimir, Ciechanowski, Kazimierz, Pei, York, Barash, Irina, Shannon, Megan, Li, Ray, Williams, Jason H., Levisetti, Matteo, Arkin, Steven, Serra, Andreas
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2017
Ábhair:
Clinical Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661280/
https://ncbi.nlm.nih.gov/pubmed/28838955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016111232
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