Potential therapeutic interventions for chronic kidney disease‐associated sarcopenia via indoxyl sulfate‐induced mitochondrial dysfunction

BACKGROUND: Chronic kidney disease (CKD) patients experience skeletal muscle wasting and decreased exercise endurance. Our previous study demonstrated that indoxyl sulfate (IS), a uremic toxin, accelerates skeletal muscle atrophy. The purpose of this study was to examine the issue of whether IS caus...

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發表在:J Cachexia Sarcopenia Muscle
Main Authors: Enoki, Yuki, Watanabe, Hiroshi, Arake, Riho, Fujimura, Rui, Ishiodori, Kana, Imafuku, Tadashi, Nishida, Kento, Sugimoto, Ryusei, Nagao, Saori, Miyamura, Shigeyuki, Ishima, Yu, Tanaka, Motoko, Matsushita, Kazutaka, Komaba, Hirotaka, Fukagawa, Masafumi, Otagiri, Masaki, Maruyama, Toru
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2017
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659061/
https://ncbi.nlm.nih.gov/pubmed/28608457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12202
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