Sirtuin-6 Preserves R-spondin-1 Expression and Increases Resistance of Intestinal Epithelium to Injury in Mice

Sirtuin-6 (Sirt6) is a critical epigenetic regulator, but its function in the gut is unknown. Here, we studied the role of intestinal epithelial Sirt6 in colitis-associated intestinal epithelial injury. We found that Sirt6, which is predominantly expressed in epithelial cells in intestinal crypts, i...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Liu, Fangyi, Bu, Heng-Fu, Geng, Hua, De Plaen, Isabelle G, Gao, Chao, Wang, Peng, Wang, Xiao, Kurowski, Jacob A, Yang, Hong, Qian, Jiaming, Tan, Xiao-Di
Formato: Artigo
Idioma:Inglês
Publicado em: Feinstein Institute for Medical Research 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654826/
https://ncbi.nlm.nih.gov/pubmed/29387864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2017.00085
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